Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Nat Cell Biol. 2000 Jul;2(7):E115-9.

Is there a cause-and-effect relationship between alpha-synuclein fibrillization and Parkinson's disease?

Author information

  • 1Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Department of Neurology, Boston, MA 02115, USA.

Abstract

The first gene to be linked to Parkinson's disease encodes the neuronal protein alpha-synuclein. Recent mouse and Drosophila models of Parkinson's disease support a central role for the process of alpha-synuclein fibrillization in pathogenesis. However, some evidence indicates that the fibril itself may not be the pathogenic species. Our own biophysical studies suggest that a structured fibrillization intermediate or an alternatively assembled oligomer may be responsible for neuronal death. This speculation can now be experimentally tested in the animal models. Such experiments will have implications for the development of new therapies for Parkinson's disease and related neurodegenerative diseases.

PMID:
10878819
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Icon for Nature Publishing Group
    Loading ...
    Write to the Help Desk