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Am J Psychiatry. 2000 Jul;157(7):1175-7.

N-Acetylaspartate concentration in the anterior cingulate of maltreated children and adolescents with PTSD.

Author information

  • 1Department of Psychiatry, University of Pittsburgh Medical Center, PA 15213, USA. DeBellisMD@msx.upmc.edu

Abstract

OBJECTIVE:

Anterior cingulate dysfunction has been implicated in the pathophysiology of posttraumatic stress disorder (PTSD). The authors hypothesized that integrity of the anterior cingulate may be affected in childhood PTSD.

METHOD:

Single voxel proton magnetic resonance spectroscopy (proton MRS) was used to measure the relative concentration of N-acetylaspartate and creatine, a marker of neural integrity, in the anterior cingulate of 11 children and adolescents who met DSM-IV criteria for PTSD secondary to maltreatment and 11 healthy matched comparison subjects.

RESULTS:

The ratio of N-acetylaspartate to creatine was significantly lower in the maltreated subjects with PTSD than in the comparison subjects.

CONCLUSIONS:

The lower N-acetylaspartate/creatine ratio in subjects with PTSD suggests that anterior cingulate neuronal metabolism may be altered in childhood PTSD.

PMID:
10873933
[PubMed - indexed for MEDLINE]
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