Display Settings:

Format

Send to:

Choose Destination
Curr Biol. 2000 Jun 15;10(12):R463-5.

Transcriptional control: imprinting insulation.

Author information

  • Sangamo Biosciences Inc, Point Richmond Tech Center, Richmond, CA 94804,USA. awolffe@sangamo.com

Abstract

Recent studies on the transcriptional regulation of two linked, imprinted genes, Igf2 and H19, have provided evidence for a novel mechanism of epigenetic control. DNA methylation controls the activity of an insulator element located between the two linked genes by regulating the binding of the zinc-finger protein CTCF.

PMID:
10873799
[PubMed - indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk