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1: Biochem Biophys Res Commun. 2000 Jun 24;273(1):27-34.Click here to read Links

Identification, gene structure, and expression of human frizzled-3 (FZD3).

Sala CF, Formenti E, Terstappen GC, Caricasole A.

Molecular Biology and Biochemistry Unit, Biology Department, GlaxoWellcome Medicines Research Centre, Via Fleming, 4, Verona, 37135, Italy.

We report the identification, genomic structure, chromosomal localization, and expression analysis of human frizzled-3 (FZD3), a 7-transmembrane receptor belonging to the frizzled family. The cDNA obtained from adult human brain shows 91% identity at the nucleotide level and 98% at the amino acid level to mouse frizzled-3 (fzd3). The FZD3 locus is located on chromosome 8p21, spans 48 Kb and its coding sequence is distributed in 6 exons intercalated by 5 introns. FZD3 is expressed in all analyzed human tissues, with quantitatively higher expression in the CNS and in urogenital structures. Copyright 2000 Academic Press.

PMID: 10873558 [PubMed - indexed for MEDLINE]