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Annu Rev Biochem. 1999;68:157-85.

Sterols and isoprenoids: signaling molecules derived from the cholesterol biosynthetic pathway.

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  • 1Department of Biological Chemistry, University of California Los Angeles 90095, USA.


Compounds derived from the isoprenoid/cholesterol biosynthetic pathway have recently been shown to have novel biological activities. These compounds include certain sterols, oxysterols, farnesol, and geranylgeraniol, as well as the diphosphate derivatives of isopentenyl, geranyl, farnesyl, geranylgeranyl, and presqualene. They regulate transcriptional and post-transcriptional events that in turn affect lipid synthesis, meiosis, apoptosis, developmental patterning, protein cleavage, and protein degradation.

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