Am J Dis Child. 1976 Dec;130(12):1318-21.

Haemophilus influenzae meningitis: an evolving therapeutic regimen.

Barkin RM, Greer CC, Schumacher CJ, McIntosh K.

Abstract

Ampicillin sodium has been the drug of choice in the treatment of Haemophilus influenzae meningitis. The development of ampicillin-resistant strains forces the clinician to focus on alternative therapies. We describe two patients in whom neutropenia was noted secondary to chloramphenicol administration, and streptomycin sulfate and sulfonamides were employed. An historical perspective summarizing the evolution of available therapeutic regimens is presented.

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[Meningitis caused by Haemophilus influenzae type B, resistant to ampicillin and chloramphenicol]. [An Esp Pediatr. 1984]
[Meningitis caused by Haemophilus influenzae type B, resistant to ampicillin and chloramphenicol].
de Juan Martín F, Aisa Iriarte ML, Boné Calvo J, Moles Calandre B. An Esp Pediatr. 1984 Aug; 21(2):153-6.
Streptomycin and sulfisoxazole for treatment of Haemophilus influenzae meningitis. [JAMA. 1978]
Streptomycin and sulfisoxazole for treatment of Haemophilus influenzae meningitis.
Meade RH 3rd. JAMA. 1978 Jan 23; 239(4):324-7.
Haemophilus influenzae type b meningitis resistant to ampicillin and chloramphenicol. [Arch Dis Child. 1986]
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Review Plasmid-mediated resistance in multiply resistant Haemophilus influenzae type b causing meningitis: molecular characterization of one strain and review of the literature.
Mendelman PM, Doroshow CA, Gandy SL, Syriopoulou V, Weigen CP, Smith AL. J Infect Dis. 1984 Jul; 150(1):30-9.

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Cited by 3 PubMed Central articles

High-performance liquid chromatographic assay of chloramphenicol in serum. [Antimicrob Agents Chemother. 1...]
High-performance liquid chromatographic assay of chloramphenicol in serum.
Koup JR, Brodsky B, Lau A, Beam TR Jr. Antimicrob Agents Chemother. 1978 Sep; 14(3):439-43.
Relationship between serum and saliva chloramphenicol concentrations. [Antimicrob Agents Chemother. 1...]
Relationship between serum and saliva chloramphenicol concentrations.
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Haemophilus influenzae meningitis: an evolving therapeutic regimen.

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