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1: Phytochemistry. 2000 Jun;54(3):311-5.Click here to read Links

3-acetylaltholactone and related styryl-lactones, mitochondrial respiratory chain inhibitors.

Peris E, Estornell E, Cabedo N, Cortes D, Bermejo A.

Departamento de Farmacología, Universidad de Valencia, Spain.

A novel furano-pyrone, 3-acetylaltholactone, and two other known styryl-lactones, altholactone and 5-acetoxyisogoniothalamin oxide, have been isolated from Goniothalamus arvensis (Annonaceae) stem bark. We report here the isolation and structural elucidation of these compounds with furane-pyrone and styryl-pyrone skeletons, postulating also for the first time their mechanism of cytotoxicity based on inhibition on mammalian mitochondrial respiratory chain.

PMID: 10870186 [PubMed - indexed for MEDLINE]