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Science. 2000 Jun 23;288(5474):2215-9.

Requirement of Mis6 centromere connector for localizing a CENP-A-like protein in fission yeast.

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  • 1CREST Research Project, Japan Science and Technology Corporation, Kyoto, Japan.

Abstract

Mammalian kinetochores contain the centromere-specific histone H3 variant CENP-A, whose incorporation into limited chromosomal regions may be important for centromere function and chromosome segregation during mitosis. However, regulation of CENP-A localization and its role have not been clear. Here we report that the fission yeast homolog SpCENP-A is essential for establishing centromere chromatin associated with equal chromosome segregation. SpCENP-A binding to the nonrepetitious inner centromeres depended on Mis6, an essential centromere connector protein acting during G1-S phase of the cell cycle. Mis6 is likely required for recruiting SpCENP-A to form proper connection of sister centromeres.

PMID:
10864871
[PubMed - indexed for MEDLINE]
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