Evaluation of an electrochemical sensor for measuring blood ketones

Diabetes Care. 2000 Apr;23(4):500-3. doi: 10.2337/diacare.23.4.500.

Abstract

Objective: To evaluate the performance of a hand-held ketone sensor that is able to measure blood beta-hydroxybutyrate (beta-HBA) concentrations within 30 s in patients with diabetic ketoacidosis (DKA) and patients who attend a weight management clinic.

Research design and methods: Two groups of patients were studied: 19 patients admitted with DKA and 156 patients attending a weight management clinic. Paired capillary and venous whole blood samples were measured using the ketone sensor and also using an enzymatic laboratory reference method.

Results: The ketone sensor accurately measured beta-HBA concentrations in patients with DKA (limits of agreement -0.9 to + 1.0 mmol/l) or starvation-induced ketonemia (limits of agreement -0.5 to +0.5 mmol/l).

Conclusions: This ketone sensor accurately measures whole blood beta-HBA concentrations within 30 s.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • 3-Hydroxybutyric Acid / blood*
  • Blood Specimen Collection / methods
  • Diabetic Ketoacidosis / blood
  • Diabetic Ketoacidosis / diagnosis*
  • Electrochemistry / instrumentation*
  • Electrochemistry / methods
  • Humans
  • Ketone Bodies / blood*
  • Reference Values
  • Reproducibility of Results

Substances

  • Ketone Bodies
  • 3-Hydroxybutyric Acid