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J Rheumatol. 2000 Jun;27(6):1546-9.

Primary cutaneous B cell lymphoma during methotrexate therapy for rheumatoid arthritis.

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  • 1Department of Medicine, Sunnybrook Health Science Centre, University of Toronto, Ontario, Canada.


A patient with rheumatoid arthritis developed a reversible, primary cutaneous, large B cell lymphoma during prolonged methotrexate (MTX) treatment. Regression of the skin lesions after discontinuation of the drug suggested a close relationship to MTX. Increased clinical awareness, discontinuation of MTX, and close observation are important in the initial management of this rare lymphoproliferative disorder.

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