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Curr Opin Neurobiol. 2000 Jun;10(3):370-4.

Homer: a link between neural activity and glutamate receptor function.

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  • 1Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

Abstract

The proteins of the Homer family bind to proline-rich sequences in group I metabotropic glutamate receptors, inositol trisphosphate receptors, ryanodine receptors, and Shank family proteins. Homer proteins also self associate and function as adaptors to couple interacting proteins. Recent observations indicate a role for Homer complexes in signal transduction, synaptogenesis and receptor trafficking.

PMID:
10851183
[PubMed - indexed for MEDLINE]
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