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J Bacteriol. 2000 Jul;182(13):3843-5.

Positive correlation between virulence of Pseudomonas aeruginosa mutants in mice and insects.

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  • 1Department of Genetics, Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.

Abstract

Strain PA14, a human clinical isolate of Pseudomonas aeruginosa, is pathogenic in mice and insects (Galleria mellonella). Analysis of 32 different PA14 mutants in these two hosts showed a novel positive correlation in the virulence patterns. Thus, G. mellonella is a good model system for identifying mammalian virulence factors of P. aeruginosa.

PMID:
10851003
[PubMed - indexed for MEDLINE]
PMCID:
PMC94559
Free PMC Article
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