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Science. 2000 Jun 9;288(5472):1835-8.

Dissociating the role of the dorsolateral prefrontal and anterior cingulate cortex in cognitive control.

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  • 1Department of Psychology, University of Pittsburgh, Pittsburgh, PA 15260, USA.

Abstract

Theories of the regulation of cognition suggest a system with two necessary components: one to implement control and another to monitor performance and signal when adjustments in control are needed. Event-related functional magnetic resonance imaging and a task-switching version of the Stroop task were used to examine whether these components of cognitive control have distinct neural bases in the human brain. A double dissociation was found. During task preparation, the left dorsolateral prefrontal cortex (Brodmann's area 9) was more active for color naming than for word reading, consistent with a role in the implementation of control. In contrast, the anterior cingulate cortex (Brodmann's areas 24 and 32) was more active when responding to incongruent stimuli, consistent with a role in performance monitoring.

PMID:
10846167
[PubMed - indexed for MEDLINE]
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