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Annu Rev Neurosci. 2000;23:73-87.

Apoptosis in neural development and disease.

Author information

  • 1Howard Hughes Medical Institute, University of Texas Southwestern Medical Center at Dallas 75235, USA. nijhawan.deepak@tumora.swmed.edu

Abstract

Cell death via apoptosis is a prominent feature in mammalian neural development. Recent studies into the basic mechanism of apoptosis have revealed biochemical pathways that control and execute apoptosis in mammalian cells. Protein factors in these pathways play important roles during development in regulating the balance between neuronal life and death. Additionally, mounting evidence indicates such pathways may also be activated during several neurodegenerative diseases, resulting in improper loss of neurons.

PMID:
10845059
[PubMed - indexed for MEDLINE]
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