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Am J Ophthalmol. 2000 May;129(5):675-6.

No clinically important effects on intraocular pressure after short-term administration of sildenafil citrate (Viagra).

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  • 1Kaiyo Clinic, Tokyo, Japan.

Abstract

PURPOSE:

To assess the short-term effects of sildenafil citrate on intraocular pressure in healthy male volunteers and participants in clinical trials.

METHODS:

Intraocular pressure and pupil diameter were measured in two placebo-controlled studies. Oral doses of sildenafil citrate (VIAGRA; Pfizer Inc, New York, New York) ranged from 10 mg to 150 mg.

RESULTS:

No major changes in intraocular pressure or pupillometry were detected at any time (1.0-24 hours) after administration of sildenafil. Additionally, of 36 subjects with a medical history of increased intraocular pressure in the sildenafil safety database, none were reported to have a clinically significant increase of their intraocular pressure. During clinical trials, two glaucoma cases were listed as serious adverse events, but were not considered treatment related.

CONCLUSION:

No clinical abnormalities were observed in intraocular pressure or pupil diameter in subjects receiving sildenafil. Currently, no evidence suggests that long-term treatment with sildenafil has an effect on intraocular pressure or is associated with the development or worsening of glaucoma.

PMID:
10844068
[PubMed - indexed for MEDLINE]
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