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Trends Biochem Sci. 2000 Jun;25(6):294-9.

ARID proteins come in from the desert.

Author information

  • 1Centre for Molecular Genetics of Development and Dept of Genetics, University of Adelaide, Adelaide, SA 5005, Australia.

Abstract

Members of the recently discovered ARID (AT-rich interaction domain) family of DNA-binding proteins are found in fungi and invertebrate and vertebrate metazoans. ARID-encoding genes are involved in a variety of biological processes including embryonic development, cell lineage gene regulation and cell cycle control. Although the specific roles of this domain and of ARID-containing proteins in transcriptional regulation are yet to be elucidated, they include both positive and negative transcriptional regulation and a likely involvement in the modification of chromatin structure.

PMID:
10838570
[PubMed - indexed for MEDLINE]
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