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    Trends Biochem Sci. 2000 Jun;25(6):294-9.

    ARID proteins come in from the desert.

    Source

    Centre for Molecular Genetics of Development and Dept of Genetics, University of Adelaide, Adelaide, SA 5005, Australia.

    Abstract

    Members of the recently discovered ARID (AT-rich interaction domain) family of DNA-binding proteins are found in fungi and invertebrate and vertebrate metazoans. ARID-encoding genes are involved in a variety of biological processes including embryonic development, cell lineage gene regulation and cell cycle control. Although the specific roles of this domain and of ARID-containing proteins in transcriptional regulation are yet to be elucidated, they include both positive and negative transcriptional regulation and a likely involvement in the modification of chromatin structure.

    PMID:
    10838570
    [PubMed - indexed for MEDLINE]

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