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Adv Drug Deliv Rev. 1997 Sep 15;27(2-3):235-256.

Improvement of oral peptide bioavailability: Peptidomimetics and prodrug strategies.

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  • 1Department of Pharmaceutical Chemistry, 2095 Constant Avenue, Simons Research Laboratories, The University of Kansas, Lawrence, KS 66047, USA


Clinical development of orally active peptide drugs has been restricted by their unfavorable physicochemical properties, which limit their intestinal mucosal permeation and their lack of stability against enzymatic degradation. Successful oral delivery of peptides will depend, therefore, on strategies designed to alter the physicochemical characteristics of these potential drugs, without changing their biological activity, in order to overcome the physical and biochemical barrier properties of the intestinal cells. This manuscript will focus on the physiological limitations for oral peptide delivery and on various strategies using chemical modifications to improve oral bioavailability of peptide-based drugs.

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