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Genes Dev. 2000 Jun 1;14(11):1313-8.

Dll4, a novel Notch ligand expressed in arterial endothelium.

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  • 1Departments of Molecular Genetics, Amgen, Inc., Thousand Oaks, California 91320 USA.


We report the cloning and characterization of a new member of the Delta family of Notch ligands, which we have named Dll4. Like other Delta genes, Dll4 is predicted to encode a membrane-bound ligand, characterized by an extracellular region containing several EGF-like domains and a DSL domain required for receptor binding. In situ analysis reveals a highly selective expression pattern of Dll4 within the vascular endothelium. The activity and expression of Dll4 and the known actions of other members of this family suggest a role for Dll4 in the control of endothelial cell biology.

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