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Philos Trans R Soc Lond B Biol Sci. 2000 Apr 29;355(1396):465-71.

Structural model of F1-ATPase and the implications for rotary catalysis.

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  • 1MRC Laboratory of Molecular Biology, Cambridge, UK.


The crystal structure of bovine mitochondrial F1-ATPase is described. Several features of the structure are consistent with the binding change mechanism of catalysis, in which binding of substrates induces conformational changes that result in a high degree of cooperativity between the three catalytic sites. Furthermore, the structure also suggests that catalysis is accompanied by a physical rotation of the centrally placed gamma-subunit relative to the approximately spherical alpha3beta3 subassembly.

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