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Hum Pathol. 2000 May;31(5):615-8.

Repeated dedifferentiation of low-grade intraosseous osteosarcoma.

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  • 1Department of Orthopedic Surgery and Pathology, Niigata University School of Medicine, Japan.


Low-grade intraosseous osteosarcoma is an uncommon bone tumor that is characterized by minimum cytological atypism and a much better prognosis than conventional osteosarcoma. This report describes a patient who had a low-grade osteosarcoma that mimicked fibrous dysplasia (FD). The tumor had an area of high-grade sarcoma at the initial diagnosis. Ten years after incomplete resection of FD-like tumor, local recurrence with areas of high-grade tumor developed. This case illustrates the potential of dedifferentiation in low-grade intraosseous osteosarcoma.

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