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Am J Psychiatry. 2000 Jun;157(6):948-55.

Association between bipolar disorder and monoamine oxidase A gene polymorphisms: results of a multicenter study.

Author information

  • 1Departement Universitaire de Psychiatrie Adulte, Lausanne, Switzerland. mpreisig@inst.hospvd.ch

Abstract

OBJECTIVE:

Although genetic factors have been implicated in the etiology of bipolar disorder, no specific gene has been conclusively identified. Given the link between abnormalities in serotonergic neurotransmission and bipolar disorder, a candidate gene association approach was applied to study the involvement of the monoamine oxidase A (MAOA) gene, which codes for a catabolic enzyme of serotonin, in the susceptibility to bipolar disorder.

METHOD:

In France and Switzerland, 272 patients with bipolar disorder and 122 healthy subjects were typed for three polymorphic markers of the MAOA gene: the MAOA-CA repeat, the MAOA restriction fragment length polymorphism (RFLP), and a repeat directly adjacent to the variable number of tandem repeats (VNTR) locus.

RESULTS:

A significant difference in the distribution of the alleles for the MAOA-CA repeat was observed between the female bipolar patients and comparison group.

CONCLUSIONS:

The results obtained in the French and Swiss population confirm findings from two studies conducted in the United Kingdom.

PMID:
10831475
[PubMed - indexed for MEDLINE]
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