Science. 1976 Apr 2;192(4234):56-9.

Carbohydrate deficiency of the factor VIII/von Willebrand factor Protein in von Willebrand's disease variants.

Abstract

Study of the normal human factor VIII/von Willebrand factor reveals a macromolecular glycoprotein composed of apparently identical subunits. This purified glycoprotein has procoagulant, antigen, and von Willebrand factor activities. In three patients with a variant of the von Willebrand's disease syndrome, their factor VIII/von Willebrand factor protein was present in normal amounts and had normal procoagulant and antigen activities; however, this protein was deficient in both carbohydrate and von Willebrand factor activity. The carbohydrate portion of the factor VIII/von Willebrand factor glycoprotein is of major importance in its interactions with platelets or the blood vessel wall, or both.

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Carbohydrate of the factor VIII/von Willebrand factor in von Willebrand's disease. [J Clin Invest. 1979]
Carbohydrate of the factor VIII/von Willebrand factor in von Willebrand's disease.
Zimmerman TS, Voss R, Edgington TS. J Clin Invest. 1979 Nov; 64(5):1298-302.
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