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Curr Opin Genet Dev. 2000 Jun;10(3):252-6.

Zebrafish: a model system for the study of human disease.

Author information

  • 1Division of Hematology/Oncology, Department of Medicine, Children's Hospital, Howard Hughes Medical Institute, Boston, Massachusetts 02115, USA.

Abstract

The zebrafish (Danio rerio) is a powerful model organism for the study of vertebrate biology, being well suited to both developmental and genetic analysis. Large-scale genetic screens have identified hundreds of mutant phenotypes, many of which resemble human clinical disorders. The creation of critical genetic reagents, coupled with the rapid progress of the zebrafish genome initiative directed by the National Institutes of Health, are bringing this model system to its full potential for the study of vertebrate biology, physiology and human disease.

PMID:
10826982
[PubMed - indexed for MEDLINE]
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