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Neurology. 2000 May 23;54(10):2009-11.

Increased CSF levels of nerve growth factor in patients with Alzheimer's disease.

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  • 1Department of Psychiatry Research, University of Zürich, Switerzland.


The authors quantitated CSF levels of nerve growth factor (NGF) in patients with AD, nondemented control subjects (CTR), and age-matched patients with major depression (DE). CSF levels of NGF were markedly higher in the AD group than in both the CTR and DE groups (p < 0.01 and p < 0.001). Increased CSF levels of NGF in AD patients may reflect reported accumulation of NGF in the AD brain and may constitute a candidate marker for clinical diagnosis and therapeutic monitoring.

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