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Tokai J Exp Clin Med. 1999 Dec;24(4-6):147-53.

Theoretical background for inward rectification.

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  • 1Department of Physiology, Tokai University School of Medicine, Bohseidai, Isehara, Japan.


Theoretical background has been reviewed for inward rectification due to a potassium current termed IRK. The Eyring rate theory in which the thermodynamic rate coefficient for chemical reactants (channels and ions in this case) can be described in terms of energy barriers for potassium ions can mimic not only the polarity and degree of rectification but also the voltage-dependence of the barium-induced IRK block. The model predicts that the blocking site locates 30-70% depth from the outer margin of the IRK channel.

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