Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Biochem J. 2000 Jun 1;348 Pt 2:241-55.

Rho GTPases and their effector proteins.

Author information

  • 1MRC Laboratory for Molecular Cell Biology, University College London, Gower Street, London WC1E 6BT, U.K. anne.bishop@ucl.ac.uk

Abstract

Rho GTPases are molecular switches that regulate many essential cellular processes, including actin dynamics, gene transcription, cell-cycle progression and cell adhesion. About 30 potential effector proteins have been identified that interact with members of the Rho family, but it is still unclear which of these are responsible for the diverse biological effects of Rho GTPases. This review will discuss how Rho GTPases physically interact with, and regulate the activity of, multiple effector proteins and how specific effector proteins contribute to cellular responses. To date most progress has been made in the cytoskeleton field, and several biochemical links have now been established between GTPases and the assembly of filamentous actin. The main focus of this review will be Rho, Rac and Cdc42, the three best characterized mammalian Rho GTPases, though the genetic analysis of Rho GTPases in lower eukaryotes is making increasingly important contributions to this field.

PMID:
10816416
[PubMed - indexed for MEDLINE]
PMCID:
PMC1221060
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Icon for Portland Press Icon for PubMed Central
    Loading ...
    Write to the Help Desk