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J Org Chem. 2000 Jan 28;65(2):445-9.

Peloruside A: a potent cytotoxic macrolide isolated from the new zealand marine sponge Mycale sp.

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  • 1School of Chemical and Physical Sciences, Victoria, University of Wellington, New Zealand.


A novel, polyoxygenated, pyranose ring containing 16-membered macrolide peloruside A (1) exhibiting cytotoxic activity in the nanomolar range was isolated from the New Zealand marine sponge Mycale sp. The structure of 1 and relative stereochemistry of the 10 stereogenic centers were determined on a 3 mg sample using a variety of spectroscopic methods. Compound 1 was isolated along with the previously reported cytotoxins mycalamide A (2) and pateamine (3) from a single specimen of this sponge.

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