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Ross Fiziol Zh Im I M Sechenova. 2000 Feb;86(2):190-5.

[Quantitative characteristics of the systemic anaphylaxis model in Sprague-Dawley rats].

[Article in Russian]

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  • 1Subdivision of the Institute of Bioorganic Chemistry of the Russian Acad. Sci., Moscow, Russia.


Anaphylactic response intensity was quantitatively estimated by means of measuring mean arterial pressure (MAP) and heart rate (HR). Damage to intestinal mucosa was studied by means of morphometry. These indices grew in a dose-dependent way along with the amount of administered egg ovalbumin (OVA). The MAP and HR measurements seem to be useful in a quantitative elucidation of allergic sensitivity in laboratory animals.

[PubMed - indexed for MEDLINE]
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