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Gut. 2000 Jun;46(6):768-73.

A valid, accurate, office based non-radioactive test for gastric emptying of solids.

Author information

  • 1Gastroenterology Research Unit, Mayo Clinic and Mayo Foundation, Rochester, Minnesota, USA.

Abstract

BACKGROUND:

Current breath tests for measurement of gastric emptying of solids are expensive, possibly inaccurate, and require cumbersome calculations.

AIMS:

We wished to validate a simplified solid gastric emptying test using a [(13)C]Spirulina platensis breath test for accurate results relative to scintigraphy.

SUBJECTS:

Thirty healthy volunteers.

METHODS:

We measured gastric emptying of egg containing [(13)C]S platensis and (99m)Tc sulphur colloid by breath (13)CO(2) and scintigraphy over six hours. A generalised linear regression model was used to predict t(1/2) and t(LAG) by scintigraphy from breath (13)CO(2) data. The model was cross validated and normative data calculated for a prepacked [(13)C]meal.

RESULTS:

Regression models using all breath data over six hours, for the first three hours, and for samples at 75, 90, and 180 minutes ("reduced model") predicted t(1/2) and t(LAG) values similar to scintigraphy (t(LAG) 43 (SD 12) min; t(1/2) 100 (20) min). Standard deviations of differences in t(1/2) and t(LAG) between scintigraphy and the "reduced model" were both 10 minutes. Gastric t(1/2) for the prepacked [(13)C]meal was 91 (15) min (10-90% range: 74-118).

CONCLUSION:

The [(13)C]S platensis breath test and a simple formula using breath (13)CO(2) at baseline, 90, and 180 minutes measured gastric emptying t(1/2) for solids with results that were comparable with scintigraphy.

PMID:
10807886
[PubMed - indexed for MEDLINE]
PMCID:
PMC1756454
Free PMC Article

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