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    Gene. 2000 May 2;248(1-2):1-14.

    Ubiquitin-like proteins: new wines in new bottles.

    Yeh ET, Gong L, Kamitani T.

    Source

    Divisions of Cardiology and Molecular Medicine, Medical School, and Research Center for Cardiovascular Diseases, Institute of Molecular Medicine for the Prevention of Human Diseases, The University of Texas-Houston Health Science Center, Houston, USA.

    Abstract

    Ubiquitin is a small polypeptide that covalently modifies other cellular proteins and targets them to the proteasome for degradation. In recent years, ubiquitin-dependent proteolysis has been demonstrated to play a critical role in the regulation of many cellular processes, such as cell cycle progression, cell signaling, and immune recognition. The recent discovery of three new ubiquitin-like proteins, NEDD8, Sentrin/SUMO, and Apg12, has further broadened the horizon of this type of post-translational protein modification. This review will focus on the biology and biochemistry of the Sentrin/SUMO and NEDD8 modification pathways, which are clearly distinct from the ubiquitination pathway and have unique biological functions.

    PMID:
    10806345
    [PubMed - indexed for MEDLINE]

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