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Ann Neurol. 2000 May;47(5):662-5.

Motor benefit from levodopa in spastic quadriplegic cerebral palsy.

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  • 1Department of Neurology, Pediatric Neurology Cerebral Palsy Center, St Louis Children's Hospital, MO 63110, USA.


We report on a 16-year-old girl with spastic quadriplegic cerebral palsy associated with premature birth and typical periventricular leukomalacia, who had a dramatic improvement in motor function after treatment with carbidopa/levodopa. Kinematic and electromyographic analyses of reaching movements demonstrate that levodopa decreased muscle co-contraction, decreased unwanted movements, and improved her ability to maintain a steady arm posture. These findings suggest that levodopa be considered as an adjunct therapy for the treatment of spastic quadriplegic cerebral palsy.

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