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Neurology. 2000 May 9;54(9):1848-50.

Creatine monohydrate in muscular dystrophies: A double-blind, placebo-controlled clinical study.

Author information

  • 1Friedrich-Baur-Institute, Ludwig-Maximilians-University of Munich, Germany. Maggie.Walter@lrz.uni-muenchen.de

Abstract

The authors assessed the safety and efficacy of creatine monohydrate (Cr) in various types of muscular dystrophies in a double-blind, crossover trial. Thirty-six patients (12 patients with facioscapulohumeral dystrophy, 10 patients with Becker dystrophy, 8 patients with Duchenne dystrophy, and 6 patients with sarcoglycan-deficient limb girdle muscular dystrophy) were randomized to receive Cr or placebo for 8 weeks. There was mild but significant improvement in muscle strength and daily-life activities by Medical Research Council scales and the Neuromuscular Symptom Score. Cr was well tolerated throughout the study period.

PMID:
10802796
[PubMed - indexed for MEDLINE]
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