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Nat Med. 2000 May;6(5):513-9.

Mitochondrial control of cell death.

Author information

  • 1Centre National de la Recherche Scientifique, CNRS-ULR1599, Institut Gustave Roussy 24 rue Calmette Desmoulins, F-94805 Villejuif. kroemer@infobiogen.fr


In many instances, permeabilization of mitochondrial membranes is a rate-limiting step of apoptotic or necrotic cell demise. This has important consequences for the pathophysiology of cell death, as well as for its pharmacological control.

[PubMed - indexed for MEDLINE]
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