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Curr Opin Cell Biol. 2000 Jun;12(3):355-60.

Nuclear transport and transcription.

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  • 1Department of Biochemistry and Biophysics, University of California, San Francisco, CA 94143-0448, USA.


The compartmentalization of DNA in the nucleus of eukaryotic cells establishes a connection between the nuclear transport machinery and the transcriptional apparatus. General transcription factors, as well as specific transcriptional activators and repressors, such as p53 and NF-AT, need to be imported into the nucleus following their translation. In addition, nuclear transport plays a crucial role in regulating the activity of many transcription factors.

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