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Curr Biol. 2000 May 4;10(9):R344-7.

Lymphocyte signaling: Cbl sets the threshold for autoimmunity.

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  • 1Division of Tumor Immunology, Department of Cancer Immunology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, 02115, USA. christopher_rudd@dfci.harvard.edu


Cbl, a negative regulator of immune signaling, has recently been shown to act as a ubiquitin-protein ligase. Further, two new papers describing Cbl-b-deficient mice suggest that Cbl-b sets the threshold of signaling in T and B cells and prevents the development of autoimmunity.

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