How to activate p53. [Curr Biol. 2000]

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1: Curr Biol. 2000 Apr 20;10(8):R315-7. Links

How to activate p53.

Caspari T.

MRC Cell Mutation Unit, University of Sussex, Brighton, BN1 9RR, UK. T.Caspari@sussex.ac.uk

The tumour suppressor protein p53 is stabilised and activated in response to ionising radiation. This is known to depend on the kinase ATM; recent results suggest ATM acts via the downstream kinase Chk2/hCds1, which stabilises p53 at least in part by direct phosphorylation of residue serine 20.

PMID: 10801407 [PubMed - indexed for MEDLINE]

ATM and Chk2-dependent phosphorylation of MDMX contribute to p53 activation after DNA damage.
EMBO J. 2005 Oct 5; 24(19):3411-22. Epub 2005 Sep 15.

[EMBO J. 2005]
ATM-dependent phosphorylation of Mdm2 on serine 395: role in p53 activation by DNA damage.
Genes Dev. 2001 May 1; 15(9):1067-77.

[Genes Dev. 2001]
Phosphorylation of Hdmx mediates its Hdm2- and ATM-dependent degradation in response to DNA damage.
Proc Natl Acad Sci U S A. 2005 Apr 5; 102(14):5056-61. Epub 2005 Mar 23.

[Proc Natl Acad Sci U S A. 2005]
ReviewRegulation of p53 in response to DNA damage.
Oncogene. 1999 Dec 13; 18(53):7644-55.

[Oncogene. 1999]
ReviewGeminin and p53: deterrents to rereplication in human cancer cells.
Cell Cycle. 2003 Jul-Aug; 2(4):283-6.

[Cell Cycle. 2003]
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[Proc Natl Acad Sci U S A. 2006]
Deregulation of DNA damage signal transduction by herpesvirus latency-associated M2.
Liang X, Pickering MT, Cho NH, Chang H, Volkert MR, Kowalik TF, Jung JU. J Virol. 2006 Jun; 80(12):5862-74.

[J Virol. 2006]
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