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Lancet. 2001 Nov 17;358(9294):1729-30.
Zonulin, a newly discovered modulator of intestinal permeability, and its expression in coeliac disease.
We identified zonulin, a novel human protein analogue to the Vibrio cholerae derived Zonula occludens toxin, which induces tight junction disassembly and a subsequent increase in intestinal permeability in non-human primate intestinal epithelia. Zonulin expression was raised in intestinal tissues during the acute phase of coeliac disease, a clinical condition in which tight junctions are opened and permeability is increased.
PMID: 10801176 [PubMed - indexed for MEDLINE]
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Cited by 8 PubMed Central articles
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Reducing small intestinal permeability attenuates colitis in the IL10 gene-deficient mouse.
Arrieta MC, Madsen K, Doyle J, Meddings J.
Gut. 2009 Jan; 58(1):41-8. Epub 2008 Oct 1.
[Gut. 2009]
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Gliadin induces an increase in intestinal permeability and zonulin release by binding to the chemokine receptor CXCR3.
Lammers KM, Lu R, Brownley J, Lu B, Gerard C, Thomas K, Rallabhandi P, Shea-Donohue T, Tamiz A, Alkan S, et al.
Gastroenterology. 2008 Jul; 135(1):194-204.e3. Epub 2008 Mar 21.
[Gastroenterology. 2008]
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Zonula occludens toxin synthetic peptide derivative AT1002 enhances in vitro and in vivo intestinal absorption of low molecular weight heparin.
Motlekar NA, Fasano A, Wachtel MS, Youan BB.
J Drug Target. 2006 Jun; 14(5):321-9.
[J Drug Target. 2006]
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