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Hum Hered. 2000 Mar-Apr;50(2):133-9.

Model-free analysis and permutation tests for allelic associations.

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  • 1Department of Psychological Medicine, Institute of Psychiatry, St. Bartholomew's and Royal London School of Medicine and Dentistry, London, UK. j.zhao@iop.kcl.ac.uk


In this short report, we address some practical problems in performing likelihood-based allelic association analysis of case-control data. Model-free statistics are proposed and their properties assessed by simulation, and procedures based on permutation tests are described for marker-marker as well as marker-disease associations. A memory-efficient algorithm is developed which enables several highly polymorphic markers to be analysed.

Copyright 1999 S. Karger AG, Basel

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