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Hum Hered. 2000 Mar-Apr;50(2):133-9.

Model-free analysis and permutation tests for allelic associations.

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  • 1Department of Psychological Medicine, Institute of Psychiatry, St. Bartholomew's and Royal London School of Medicine and Dentistry, London, UK.


In this short report, we address some practical problems in performing likelihood-based allelic association analysis of case-control data. Model-free statistics are proposed and their properties assessed by simulation, and procedures based on permutation tests are described for marker-marker as well as marker-disease associations. A memory-efficient algorithm is developed which enables several highly polymorphic markers to be analysed.

Copyright 1999 S. Karger AG, Basel

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