Format

Send to

Choose Destination
See comment in PubMed Commons below
J Neurosci Res. 2000 May 15;60(4):427-36.

Ephrins stimulate or inhibit neurite outgrowth and survival as a function of neuronal cell type.

Author information

  • 1Department of Chemical Biology, Laboratory for Cancer Research, College of Pharmacy, Rutgers University, NJ, USA.

Abstract

The Eph family of tyrosine kinase receptors and ligands play key roles in cell segregation and axon targeting in the developing nervous system. Interactions between the ligands and receptors cause repulsion or degeneration of receptor-positive axons from several brain regions including the retina, hippocampus, thalamus, and midbrain dopaminergic system. We extend these previous observations by showing that three A-ephrins also negatively regulate the growth of neurites from striatal and olfactory neurons. In addition to negative effects, however, we also report a trophic activity of the A-ephrins: Ephrin-A2 and A5 promote survival and neurite outgrowth of sympathetic neurons. These observations provide support to the notion that ephrins may function as either negative or positive signals in the developing nervous system.

Copyright 2000 Wiley-Liss, Inc.

LinkOut - more resources

Full Text Sources

Other Literature Sources

PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Wiley
    Loading ...
    Write to the Help Desk