Format

Send to

Choose Destination
See comment in PubMed Commons below
Bioessays. 2000 May;22(5):460-8.

hedgehog and wing development in Drosophila: a morphogen at work?

Author information

  • 1Evolution et Développement des Protostomien,Centre de Génétique Moléculaire-UMR 2067 CNRS; 1, avenue de la terrasse, F-91198 Gif-sur-Yvette Cedex, France. vervoort@cgm.cnrs-gif.fr

Abstract

In Drosophila, Hedgehog (Hh) is a key regulator of limb development and activates decapentaplegic (dpp), a gene encoding a TGFbeta-related factor that controls growth and patterning of the limbs. During wing development, Hh also has morphogen-like Dpp-independent functions, controlling the morphogenesis of the central part of the wing through the activation of the evolutionarily conserved transcription factors encoded by the iroquois and collier genes. The ways in which Hh forms an activity gradient to lay the basis of patterning of the adult wing are described here. As the signal transduction pathway of Hh is strongly conserved during evolution and human Hh may be implicated in congenital diseases and cancers, these observations provide important advances which may help in understanding the function of Hh proteins in normal and pathological development and tumourigenesis in humans.

LinkOut - more resources

Full Text Sources

Molecular Biology Databases

PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Wiley
    Loading ...
    Write to the Help Desk