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Cochrane Database Syst Rev. 2000;(2):CD000115.

Intrapartum antibiotics for group B streptococcal colonisation.

Author information

  • Department of Pathology and Molecular Medicine, McMaster University Medical Centre, Hamilton Health Sciences Corporation, Room 2N29, 1200 Main Street West, Hamilton, Ontario, Canada, L8N 3Z5. smaill@mcmaster.ca.

Abstract

BACKGROUND:

Group B streptococcal infection is common in pregnant women without causing harm. However it is also a significant cause of neonatal morbidity and mortality.

OBJECTIVES:

The objective of this review was to assess the effects of intrapartum administration of antibiotics to women on infant colonization with group B streptococcus, early onset neonatal group B streptococcus sepsis and neonatal death from infection.

SEARCH STRATEGY:

The Cochrane Pregnancy and Childbirth Group trials register was searched.

SELECTION CRITERIA:

Controlled trials of pregnant women colonized with group B streptococcus comparing intrapartum antibiotic administration with no treatment, and providing data on infant colonization with group B streptococcus and/or neonatal infection.

DATA COLLECTION AND ANALYSIS:

Eligibility and trial quality assessment were done by one reviewer.

MAIN RESULTS:

Five trials were included. Overall quality was poor, with potential selection bias in all the identified studies. Intrapartum antibiotic treatment reduced the rate of infant colonization (odds ratio 0.10, 95% confidence interval 0.07 to 0.14) and early onset neonatal infection with group B streptococcus (odds ratio 0.17, 95% confidence interval 0.07 to 0. 39). A difference in neonatal mortality was not seen (odds ratio 0. 12, 95% confidence interval 0.01 to 2.00).

REVIEWER'S CONCLUSIONS:

Intrapartum antibiotic treatment of women colonized with group B streptococcus appears to reduce neonatal infection. Effective strategies to detect maternal colonization with group B streptococcus and better data on maternal risk factors for neonatal group B streptococcus infection in different populations are required.

PMID:
10796138
[PubMed - indexed for MEDLINE]
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