Format

Send to:

Choose Destination
See comment in PubMed Commons below
Cochrane Database Syst Rev. 2000;(2):CD000027.

Antihistamines versus aspirin for itching in late pregnancy.

Author information

  • 1Barn Croft Surgery, Temple Sowerby, Penrith, Cumbria, CA10 1RZ. youngjckvg@compuserve.com

Abstract

BACKGROUND:

While not common, itching in pregnancy (not due to liver disease) can be distressing.

OBJECTIVES:

The objective of this review was to assess the effects of treatment for itching in late pregnancy.

SEARCH STRATEGY:

We searched the Cochrane Pregnancy and Childbirth Group trials register. In addition, the Cochrane Controlled Trials Register (CENTRAL/CCTR) was searched. Date of last search: April 1999.

SELECTION CRITERIA:

Randomised trials of treatments for itching in women in late pregnancy with normal liver function.

DATA COLLECTION AND ANALYSIS:

Trial quality was assessed and data were extracted independently by two reviewers.

MAIN RESULTS:

One study of 38 women was included. This was a small crossover trial, using alternate allocation. The trial compared a histamine, chlorpheniramine, with aspirin. Aspirin was more effective than chlorpheniramine in relieving itching (odds ratio 2. 39, 95% confidence interval 1.25 to 4.57). However chlorpheniramine was more effective than aspirin when a rash was present.

REVIEWER'S CONCLUSIONS:

Aspirin appears to be more effective than chlorpheniramine for relief of itching in pregnancy when no rash is present. If there is a rash, chlorpheniramine may be more effective.

PMID:
10796091
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for John Wiley & Sons, Inc.
    Loading ...
    Write to the Help Desk