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Hepatogastroenterology. 2000 Mar-Apr;47(32):468-72.

The role of vitamin D3 receptor mRNA in the proliferation of hepatocellular carcinoma.

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  • 1Department of Medicine, Tokyo Metropolitan Otsuka Hospital, Japan.



1,25-Dihydroxyvitamin D3 [1,25-(OH)2D3] exhibits effects on cell proliferation and differentiation.


We examined the anti-proliferative effect of 1,25-(OH)2D3 on human hepatocellular carcinoma cell lines (PLC/PRF/5, HCC-T) and the role of vitamin D receptors in modulating this effect. We also investigated the gene expression of vitamin D receptors in tissues from patients with hepatocellular carcinoma.


1,25-(OH)2D3 inhibited proliferation of PLC/PRF/5 cells that express prominent vitamin D receptor mRNA with time and dose dependent manner. On the other hand 1,25-(OH)2D3 had no anti-proliferative effect on hepatocellular carcinoma T cells in which gene expression of vitamin D receptor was little. We next examined vitamin D receptor gene expression in surgically obtained 10 hepatocellular carcinoma tissues by reverse transcriptase-polymerase chain reaction analysis. In all 10 cases, the level of vitamin D receptor mRNA in tumorous tissue was expressed on tumorous tissue.


These results indicate that 1,25-(OH)2D3 may clinically exert its anti-proliferative effect through vitamin D receptors.

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