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Ann Endocrinol (Paris). 2000 Feb;61(1):41-6.

Identification and role of aldosterone receptors in the cardiovascular system.

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  • 1INSERM U 478, IFR02, Faculté de Médécine Xavier Bichat, 16, rue Henri Huchard, 75870 Paris Cedex 18, France.

Abstract

The cardiovascular system is now recognized as an important mineralocorticoid target. All -components required for specific and selective aldosterone effects are present in the cardiovascular system. Mineralocorticoid receptors (MR) are expressed in the heart and large blood vessels together with the 11 B-hydroxysteroid dehydrogenase type II, which ensures the enzymatic protection of MR against glucocorticoids. The recent description of local vascular and cardiac aldosterone biosynthesis strongly supports an autocrine/paracrine hormonal action. Establishment of transgenic mice models of targeted overexpression of the mineralocorticoid receptor should facilitate new insights into the molecular and cellular mechanisms of aldo-sterone actions in the cardiovascular system.

PMID:
10790591
[PubMed - indexed for MEDLINE]
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