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Proc Int Conf Intell Syst Mol Biol. 1999:60-7.

Automatic extraction of biological information from scientific text: protein-protein interactions.

Blaschke C, Andrade MA, Ouzounis C, Valencia A.

Protein Design Group, CNB-CSIC, Madrid, Spain.

We describe the basic design of a system for automatic detection of protein-protein interactions extracted from scientific abstracts. By restricting the problem domain and imposing a number of strong assumptions which include pre-specified protein names and a limited set of verbs that represent actions, we show that it is possible to perform accurate information extraction. The performance of the system is evaluated with different cases of real-world interaction networks, including the Drosophila cell cycle control. The results obtained computationally are in good agreement with current biological knowledge and demonstrate the feasibility of developing a fully automated system able to describe networks of protein interactions with sufficient accuracy.

PMID: 10786287 [PubMed - indexed for MEDLINE]

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