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Trends Microbiol. 2000 May;8(5):238-44.

The eukaryotic-like Ser/Thr protein kinases of Mycobacterium tuberculosis.

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  • 1Divn of Infectious Diseases, University of British Columbia, 2733 Heather St, Vancouver, BC, Canada.


In bacteria, extracellular signals are generally transduced into cellular responses via a two-component system. However, genome sequence data have now revealed the presence of 'eukaryotic-like' protein kinases and phosphatases. Mycobacterium tuberculosis appears to be unique among bacteria in that its genome contains 11 members of a newly identified protein kinase family. These M. tuberculosis eukaryotic-like protein kinases could be key regulators of metabolic processes, including transcription, cell development and interactions with host cells.

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