Display Settings:

Format

Send to:

Choose Destination
Am J Psychiatry. 2000 May;157(5):818-20.

Divalproex treatment for youth with explosive temper and mood lability: a double-blind, placebo-controlled crossover design.

Author information

  • 1Department of Therapeutics, Division of Epidemiology of Brain Disorders, New York State Psychiatric Institute, New York, NY 10032, USA. sd45@columbia.edu

Erratum in

  • 2000 Jul;157(7):1192.
  • Am J Psychiatry 2000 Jun;157(6):1038.

Abstract

OBJECTIVE:

The authors sought to replicate open-label findings showing that specific criteria for explosive temper and mood lability identify disruptive youth who improve while receiving the anticonvulsant divalproex sodium.

METHOD:

Twenty outpatient children and adolescents (ages 10-18) with a disruptive behavior disorder (oppositional defiant disorder or conduct disorder) met the specific criteria for explosive temper and mood lability. They received 6 weeks of divalproex treatment and 6 weeks of placebo by random assignment. Independent evaluators blind to group assignment assessed response at the end of each phase.

RESULTS:

At the end of phase 1, eight of 10 subjects had responded to divalproex; zero of 10 had responded to placebo. Of the 15 subjects who completed both phases, 12 has superior response taking divalproex.

CONCLUSIONS:

This preliminary study replicates open-label findings showing that divalproex is an efficacious treatment for explosive temper and mood lability in disruptive children and adolescents.

PMID:
10784478
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Silverchair Information Systems
    Loading ...
    Write to the Help Desk