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Science. 2000 Apr 28;288(5466):678-82.

Location of a major susceptibility locus for familial schizophrenia on chromosome 1q21-q22.

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  • 1Center for Molecular and Behavioral Neuroscience, Rutgers University, Newark, NJ 07102, USA.


Schizophrenia is a complex disorder, and there is substantial evidence supporting a genetic etiology. Despite this, prior attempts to localize susceptibility loci have produced predominantly suggestive findings. A genome-wide scan for schizophrenia susceptibility loci in 22 extended families with high rates of schizophrenia provided highly significant evidence of linkage to chromosome 1 (1q21-q22), with a maximum heterogeneity logarithm of the likelihood of linkage (lod) score of 6.50. This linkage result should provide sufficient power to allow the positional cloning of the underlying susceptibility gene.

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