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Trends Biochem Sci. 2000 May;25(5):229-35.

Phosphoinositide signaling and the regulation of membrane trafficking in yeast.

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  • 1Dept of Cellular and Molecular Medicine and Howard Hughes Medical Institute, University of California, San Diego, La Jolla, CA 92093-0668, USA.


Phosphoinositides are key regulators of diverse cellular processes in eukaryotic cells. Genetic studies in yeast have advanced our understanding of how phosphoinositide-signaling pathways regulate membrane trafficking. Enzymes required for the synthesis (kinases) and turnover (phosphatases) of distinct phosphoinositides have been identified and several downstream effector molecules linked to phosphoinositide signaling have recently been characterized.

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