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Am J Cardiol. 2000 May 1;85(9):1151-3, A10.

Generic antiarrhythmics are not therapeutically equivalent for the treatment of tachyarrhythmias.

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  • 1The Electrophysiology Service, Division of Cardiology, Department of Medicine, Columbia University and The New York Presbyterian Hospital, New York, NY, USA.


The consequences of antiarrhythmic drug formulation substitution were assessed by survey of 130 experts on arrhythmias. Fifty-four arrhythmia recurrences, 7 proarrhythmic events, and 3 deaths resulting from generic substitution are reported, thus raising serious concerns about both antiarrhythmic drug substitution and the adequacy of the generic drug approval process.

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